Excision Repair in Mammalian Cells
نویسندگان
چکیده
منابع مشابه
Base excision repair intermediates are mutagenic in mammalian cells
Base excision repair (BER) is the main pathway for repair of DNA damage in mammalian cells. This pathway leads to the formation of DNA repair intermediates which, if still unsolved, cause cell lethality and mutagenesis. To characterize mutations induced by BER intermediates in mammalian cells, an SV-40 derived shuttle vector was constructed carrying a site-specific lesion within the recognition...
متن کاملMammalian Base Excision Repair: the Forgotten Archangel
Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens. This fundamental and essential function of BER not only necessitates tight control of the continuous...
متن کاملMammalian nucleotide excision repair and syndromes.
Mammalian nucleotide excision repair and syndromes W. Vermeulcn*, J. de Boer*, E. Citterio*, A. J. van Gool*, G. T. J. van der Horst*, N. G. J. Jaspers*, W. L. dc Laat*, A. M. Sijbers*, P. J. van der Spek*, K. Sugasawa*, G. Weeda*, G. S. Winkler*, D. Bootsma*, J.-M. Egly-land J. H. J. Hoeijmakers. *Department of Genetics, Medical Genetics Centre, Erasmus University, P.O. Box I 738, 3000DR Rotte...
متن کاملLong-patch DNA repair synthesis during base excision repair in mammalian cells.
The base excision repair (BER) process removes base damage such as oxidation, alkylation or abasic sites. Two BER sub-pathways have been characterized using in vitro methods, and have been classified according to the length of the repair patch as either 'short-patch' BER (one nucleotide) or 'long-patch' BER (LP-BER; more than one nucleotide). To investigate the occurrence of LP-BER in vivo, we ...
متن کاملLong patch base excision repair in mammalian mitochondrial genomes.
The mitochondrial genome is highly susceptible to damage by reactive oxygen species (ROS) generated endogenously as a byproduct of respiration. ROS-induced DNA lesions, including oxidized bases, abasic (AP) sites, and oxidized AP sites, cause DNA strand breaks and are repaired via the base excision repair (BER) pathway in both the nucleus and mitochondria. Repair of damaged bases and AP sites i...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.27.15915